Preheat the oven to 300 degrees F (150 degrees C). Coat a 9x5 inch loaf pan with cooking spray. Line a baking sheet with aluminum foil.
Heat a large skillet over medium high heat. Add beef and pork; cook, breaking up meat with a wooden spoon, until brown and crumbly, 5 to 7 minutes. Drain and discard grease. Add spaghetti sauce and brown sugar; stir until well blended. Set aside.
Combine cottage cheese, blue cheese, Parmesan cheese, egg, and oregano in a bowl.
Spread 1 inch sauce in the bottom of the prepared loaf pan.
Break and arrange 2 lasagna noodles to fit length of the pan, slightly overlapping.
Spread 1/2 cottage cheese mixture on top noodle layer; layer 3 overlapping slices provolone on top cottage cheese mixture.
Sprinkle 1/2 Cheddar cheese on top provolone.
Repeat layering with remaining sauce, noodles, cottage cheese mixture, provolone, and Cheddar cheese, ending with a sauce layer.
Place loaf pan on the prepared baking sheet; cover loosely with aluminum foil.
Bake in the preheated oven until bubbling and cooked through, about 1 ½ hours. Set aside before slicing, about 15 minutes.
Blue Cheese Lasagna · Dinner Match Lab | Dinner Match Lab